Chinese Journal of Clinicians, Vol 6, No 7 (2012)

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Experimental study on standardizing magnetic resonance portal venography in healthy piglets

YANG Zhen-feng, CHEN Tian-wu, REN Yong-jun, WANG Li-ying, ZHOU Li, ZHANG Xiao-ming, ZHAI Zhao-hua, LI Rui

Abstract


  Objective To standardize the technique of magnetic resonance(MR)portal venography in healthy piglets by utilizing digital subtraction angiography(DSA)as the gold standard.Methods Sixteen healthy piglets were enrolled into this study and underwent MR perfusion scans in the condition of general anesthesia,and the dynamic scanning volume encompassed the main portal vein.By the GE perfusion commercial software,the time-signal curve of portal vein was generated automatically to obtain the time of portal vein peak enhancement for optimizing imaging time of MR portal venography.Twenty-four hours after the dynamic study,the fat-suppressed three-dimensional fast gradient echo sequence(3D FSPGR)MR coronal enhancement scanning was carried out in the experimental animals according to the above-mentioned optimal imaging time of MR portal venography,and the coronal imaging data were used for multiplanar volume reconstruction to display the main portal vein and principal branches and measure their caliber.Subsequently,each piglet underwent indirect portography via superior mesenteric artery and splenic artery to demonstrate the mesenteric veins,splenic vein and main portal vein,and to measure their caliber.The data of indirect portography via superior mesenteric artery were randomly selected for calculating the best portal vein imaging time by this angiography.The optimal imaging time of portal venography,or the diameters of the main portal vein(MPV)and branches between MR and DSA were statistically analyzed.Results (1)The optimal imaging time of MR portal venography was significantly longer than that of DSA venography〖(31.81±2.03)s vs.(14.32±0.71)s,respectively,P<0.05〗,but there was a good correlation between MR and DSA(r=0.749,P<0.05).(2)The diameters of MPV,superior mesenteric vein and splenic vein on MR portal venography were significantly larger than those on DSA venography〖(8.82±0.78)mm vs.(7.65±1.17)mm,(7.04±0.78)mm vs.(5.74±1.05)mm,and(5.83±0.61)mm vs.(5.01±1.00)mm,respectively,all P<0.05〗,but there were significant correlations(r=0.949,0.910,0.906,respectively,all P<0.05).Conclusions The standard MR portal venography can be helpful for accurately evaluating the portal system,which might be the model for the further study on developing the standard MR portal venography technique used in experimental portal hypertension secondary to liver cirrhosis.

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Chinese Journal of Clinicians